How was the confrontation of Qom’s Islamic Seminary, as one of the influential Shi'ite seminaries in the 14th century, with deviant courses of Qur’anic science and interpretation, including eclectic and non-eclectic courses? This article discusses this issue by collecting data and information using a documentary and a descriptive-analytical method. According to this research three deviant currents have emerged in the field of interpretation, in the last century: 1. Scientism, with the orientation of the authenticity of sense and experiment (the groups of Melli-Mazhabi and Nehzat Azadi) 2. The intellectual current with a socialist and sociological orientation (part of Hoseiniya Ershad and the group of mobarez Muslim movement) 3. The quasi-Islamic Marxist trend with a political orientation based on revolutionism (the groups of Mojahedin Khalq and Furqan). Among the scholars of the Qom Islamic seminary in the last century, Allameh Tabataba’i and his students, especially Martyr Motahhari and Ayatollah Misbah Yazdi, seriously confronted these currents. The main reasons for their intellectual deviation in the interpretation of Qur’anic verses are as follows: lack of respect for necessary prerequisites and scientific foundations for a valid interpretation, self-referentiality in reading religious texts and opposition to the Islamic Seminary and clergymen.